研究業績

2019年

Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.
Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.
Sci Rep. 2019 Oct 14;9(1):14764. doi: 10.1038/s41598-019-51462-9.

Aoyama T, Takasawa A, Takasawa K, Ono Y, Emori M, Murata M, Hayasaka T, Fujitani N, Osanai M, Yamashita T, Hasegawa T, Sawada N.

Identification of Coiled-Coil Domain-Containing Protein 180 and Leucine-Rich Repeat-Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue.

Am J Pathol. 2019 Feb. doidoi: 10.1016/j.ajpath.2019.01.013.

PMID: 30790560

Ino Y, Akimoto T, Takasawa A, Takasawa K, Aoyama T, Ueda A, Ota M, Magara K, Tagami Y, Murata M, Hasegawa T, Saito T, Sawada N, Osanai M.
Elevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma.
Histol Histopathol. 2019 Sep 4:18157. doi: 10.14670/HH-18-157.

Hayasaka N, Takada K, Nakamura H, Arihara Y, Kawano Y, Osuga T, Murase K, Kikuchi S, Iyama S, Emori M, Sugita S, Hasegawa T, Takasawa A, Miyanishi K, Kobune M, Kato J.
Combination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells.
Sci Rep. 2019 Apr 8;9(1):5759. doi: 10.1038/s41598-019-42300-z.

 

2018年

Osanai M, Takasawa A, Takasawa K, Murata M, Sawada N.

Retinoic acid-metabolizing enzyme cytochrome P450 26A1 promotes skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.

Oncol Lett. 2018 Jun;15(6):9987-9993. doi: 10.3892/ol.2018.8599. Epub 2018 Apr 27.

PMID: 29928370

Aoyama T, Takasawa A, Murata M, Osanai M, Takano K, Hasagawa T, Sawada N.

Immunoreactivity patterns of tight junction proteins are useful for differential diagnosis of human salivary gland tumors.

Med Mol Morphol. 2018 Jun 28. doi: 10.1007/s00795-018-0199-6. [Epub ahead of print]

PMID: 29955965

Tanaka S, Aoyama T, Ogawa M, Takasawa A, Murata M, Osanai M, Saito T, Sawada N.

Cytotoxicity of Clostridium perfringens enterotoxin depends on the conditions of claudin-4 in ovarian carcinoma cells.

Exp Cell Res. 2018 Oct 1;371(1):278-286. doi: 10.1016/j.yexcr.2018.08.024. Epub 2018 Aug 22.

PMID: 30142326

Akimoto T, Takasawa A, Takasawa K, Aoyama T, Murata M, Osanai M, Saito T, SawadaN.

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression.

Neoplasia. 2018 Oct;20(10):1083-1093. doi: 10.1016/j.neo.2018.08.010. Epub 2018 Sep 15.

PMID: 30227306 

Murata M, Osanai M, Takasawa A, Takasawa K, Aoyama T, Kawada Y, Yamamoto A, Ono Y, Hiratsuka Y, Kojima T, Sawada N.  Occludin induces microvillus formation via phosphorylation of ezrin in a mouse hepatic cell line.  Exp Cell Res. 2018 May 15;366(2):172-180. doi: 10.1016/j.yexcr.2018.03.018. Epub 2018 Mar 16.

PMID:29555369

 

2017年

Aoki H, Yamamoto E, Takasawa A, Niinuma T, Yamano HO, Harada T, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Aoyama T, Eizuka M, Yorozu A, Kitajima H, Kai M, Sawada N, Sugai T, Nakase H, Suzuki H.  Epigenetic silencing of SMOC1 in traditional serrated adenoma and colorectal cancer.  Oncotarget. 2017 Dec 20;9(4):4707-4721. 

doi: 10.18632/oncotarget.23523. eCollection 2018 Jan 12.

PMID:29435136

Ueda A, Takasawa A, Akimoto T, Takasawa K, Aoyama T, Ino Y, Nojima M, Ono Y, Murata M, Osanai M, Hasegawa T, Saito T, Sawada N.  Prognostic significance of the co-expression of EGFR and HER2 in adenocarcinoma of the uterine cervix. PLoS One. 2017 Aug 31;12(8):e0184123.  

doi: 10.1371/journal.pone.0184123.  eCollection 2017.

PMID:28859123

Magara K, Takasawa A, Osanai M, Ota M, Tagami Y, Ono Y, Takasawa K, Murata M, Hirohashi Y, Miyajima M, Yamada G, Hasegawa T, Sawada N.  Elevated expression of JAM-A promotes neoplastic properties of lung adenocarcinoma.  Cancer Sci. 2017 Nov;108(11):2306-2314. doi: 10.1111/cas.13385. Epub 2017 Sep 18. 

PMID:28837251

                                                                            

Osanai M, Takasawa A, Murata M, Sawada N.  Claudins in cancer.: bench to bedside.

Pflugers Arch. 2017 Jan;469(1):55-67. doi: 10.1007/s00424-016-1877-7. Epub 2016 Sep 13. Review.

PMID:27624415

Uehara Y, Takahashi M, Murata M, Saito A, Takamiya R, Hasegawa Y, Kuronuma K, Chiba H, Hashimoto J, Sawada N, Takahashi H, Kuroki Y, Ariki S. Surfactant protein A (SP-A) and SP-A-derived peptide attenuate chemotaxis of mast cells induced by human β-defensin 3.  Biochem Biophys Res Commun. 2017 Mar 25;485(1):107-112.  doi: 10.1016/j.bbrc.2017.02.028. Epub 2017 Feb 8.

PMID: 28188794

Hashimoto J, Takahashi M, Saito A, Murata M, Kurimura Y, Nishitani C, Takamiya R, Uehara Y, Hasegawa Y, Hiyama Y, Sawada N, Takahashi S, Masumori N, Kuroki Y, Ariki S.  Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection.   J Immunol. 2017 Apr 1;198(7):2898-2905.  doi: 10.4049/jimmunol.1502626. Epub 2017 Feb 22.

PMID: 28228557

Tabata S, Murata M, Takasawa A, Fukuda A, Ogasawara J, Koseki T, Nakano K, Segawa K, Morita R, Hasegawa T, Sawada N. Cytological findings of langerhans cell sarcoma in a case of quintuple cancer.

Diagn Cytopathol. 2017 May 45(5):441-445.  doi: 10.1002/dc.23628. Epub 2017 Feb 24.

PMID: 28233936

Takasawa K, Takasawa A, Osanai M, Aoyama T, Ono Y, Kono T, Hirohashi Y, Murata M, Sawada N. Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer. Cancer Lett. 2017 Sep 10;403:66-73.  doi: 10.1016/j.canlet.2017.05.033. Epub 2017 Jun 15.

PMID: 28624624

Osanai M. Cellular retinoic acid bioavailability in various pathologies and its therapeutic implication.  Pathol Int. 2017 Jun;67(6):281-291.  doi: 10.1111/pin.12532. Epub 2017 Apr 19. Review.

PMID: 28422378

 

 

2016年

Norimasa Sawada. Pathophysiology of tight junctions in human diseases.

ホメオスタシスを維持するタイト結合とヒト疾患

札幌医学雑誌、2016, 85(1-6),  13-20.  doi: 10.15114/smj.85.13

Murata M, Otsuka M, Ashida N, Yamada G, Kuronuma K, Chiba H, Takahashi H.  Surfactant protein D is a useful biomarker for monitoring acute lung injury in rats.  Exp Lung Res. 2016 Aug;42(6):314-321.  doi: 10.1080/01902148.2016.1215570.

PMID: 27541374

Ohkawa E, Hiraoka M, Abe A, Murata M, Ohguro H. Fluctuation of lysosomal phospholipase A2 in experimental autoimmune uveitis in rats. Exp Eye Res. 2016 Aug;149:66-74.  doi: 10.1016/j.exer.2016.06.017.  Epub 2016 Jun 23.

PMID: 27344956

Takasawa A, Murata M, Takasawa K, Ono Y, Osanai M, Tanaka S, Nojima M, Kono T, Hirata K, Kojima T, Sawada N.  Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer. 

Sci Rep. 2016 Sep;19;6:33582.  doi: 10.1038/srep33852.

PMID: 27641742

Osanai MTakasawa AMurata M, Tanaka S, Miura H, Hata F, Sawada N.  Vasculogenic mimicry in  gastrointestinal stromal tumor of the stomach; A case report.  Case Rep Clin Pathol, 3: 50-54, 2016. 

PMID: 27340071

Osanai MLee GH.  CYP24A1-induced vitamin D insufficiency promotes breast cancer growth.  Oncol Rep. 2016 Nov;36(5):2755-2762. doi: 10.3892/or.2016.5072. Epub 2016 Sep 5.

PMID: 27600601 

Osanai MTakasawa AMurata MSawada N.  Claudins in cancer: bench to bedside.  Pflugers Ach. 2017 Jan;469(1)55-67. doi: 10.1007/s00424-016-1877-7. Epub 2016 Sep 13. Review.

PMID: 27624415

Osanai M, Lee GH.  Elevated expression of the retinoic acid-metabolizing enzyme CYP26C1 in primary breast carcinomas.  Med Mol Morphol. 2016 Mar;49: 22-27.  doi: 10.1007/s00795-015-0110-7. Epub 2015 May 26.

PMID: 26009309

Ono Y, Hiratsuka Y, Murata M, Takasawa A, Fukuda R, Nojima M, Tanaka S, Osanai M, Hirata K, Sawada N.  Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma.  Virchows Arch. 2016 Oct;469(4):417-426.  doi: 10.1007/s00428-016-1984-z. 

PMID: 27444172

Kono T, Kondoh M, Kyuno D, Ito T, Kimura Y, Imamura M, Kohno T, Konno T, Furuhata T, Sawada N, Hirata K, Kojima T.  Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.  Pharmacol Res Perspect. 2015 Dec 20;3(6):e00196. doi: 10.1002/prp2.196. eCollection 2015 Dec.  

PMID: 27022469

Furuhashi M, Fuseya T, Murata M, Hoshina K, Ishimura S, Mita T, Watanabe Y, Omori A, Matsumoto M, Sugaya T, Oikawa T, Nishida J, Kokubu N, Tanaka M, Moniwa N, Yoshida H, Sawada N, Shimamoto K, Miura T. Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis.  Arterioscler Thromb Vasc Biol. 2016 May;36(5):825-34. doi: 10.1161/ATVBAHA.116.307225. Epub 2016 Mar 24.  

PMID: 27013610

Yamada G, Murata M, Takasawa A, Nojima M, Mori Y, Sawada N, Takahashi H. Increased expressions of claudin 4 and 7in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Med Mol Morphol. 2016 Sep;49(3):163-169. doi: 10.1007/s00795-016-0135-6. Epub 2016 Feb 12.

PMID: 26872891

Akimoto TTakasawa AMurata MKojima YTakasawa KNojima MAoyama THiratsuka YOno YTanaka SOsanai M,Hasegawa TSaito TSawada N.  Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma. Histol Histopathol. 2016 Aug;31(8):921-931.  doi: 10.14670/HH-11-729. 

Epub 2016 Feb 5.

PMID: 26847087

Horiguchi H, Kobune M, Kikuchi S, Yoshida M, Murata M, Murase K, Iyama S, Takada K, Sato T, Ono K, Hashimoto A, Tatekoshi A, Kamihara Y, Kawano Y, Miyanishi K, Sawada N, Kato J.  Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms.  Haematologica. 2016 Apr;101(4):437-47. doi: 10.3324/haematol.2015.134932. Epub 2016 Jan 22. 

PMID: 26802051

Okita K, Mizuguchi T, Shigenori O, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K.  Pancreatic regeneration: basic research and gene regulation. Surg Today. 2016 Jun; 46(6)633-40. doi: 10.1007/s00595-015-1215-2. Epub 2015 Jul 7. Review.  

PMID: 26148809

 

 

2015年

Tsujiwaki M, Murata M, Takasawa A, Hiratsuka Y, Fukuda R, Sugimoto K, Ono Y, Nojima M, Tanaka S, Hirata K, Kojima T, Sawada N. Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.  Med Mol Morphol, 48(1):33-43, 2014.  doi: 10.1007/s00795-014-0074-z.

Osanai M.  Tight junctions.  Encyclopedia of Cancer.  Fourth edition; chapter 3,5814-5823, 2015.  Schwab M (edited), Springer.

Osanai M, Lee GH. The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells. Oncol Rep, 34:850-858, 2015.

Hayashi Y, Osanai M, Lee GH. NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells.  Oncol Rep, 34(4):1650-1658, 2015. doi: 10.3892/or.2015.4171. Epub 2015 Aug 4.

Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano K, Konno T, Sawada N, Himi T, Kojima T.  Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.  Eur J Pharmacol, 2015 Aug 15;761:375-82.  doi: 10.1016/j.ejphar.2015.04.031.

Kojima T, Kondoh M, Keira T, Takano K, Kakuki T, Kaneko Y, Miyata R, Nomura K, Obata K, Kohno T, Konno T, Sawada N, Himi T. Claudin-binder C-CPE mutants enhance permeability of insulin across human nasal epithelial cells.  Drug Deliv, 2015 Jun 3:1-8.

Konno T, Ninomiya T, Kohno T, Kikuchi S, Sawada N, Kojima T.

c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elogation of human pancreatic cancer cell line HPAC in a Ca-switch model.  Histochem Cell Biol, 143(5):471-479, 2015.  

doi: 10.1007/s00418-014-1300-4.

Miyata R, Nomura K, Kakuki T, Takano K, Kohno T, Konno T, Sawada N, Himi T, Kojima T.

Irsogladine maleate regulates gap junctional intercellular communication-dependent epithelial barrier in human nasal epithelial cells.  J Membr Biol, 248(2): 327-336, 2015.  doi: 10.1007/s00232-015-9774-0.

Keira Y, Takasawa A, Murata M, Nojima M, Takasawa K, Ogino J, Higashiura Y, Sasaki A, Kimura Y, Mizuguchi T, Tanaka S, Hirata K, Sawada N, Hasegawa T.  An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens. Virchows Arch, 466(3): 265-277, 2015. doi: 10.1007/s00428-014-1705-4.

 

2014年

Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S. 

Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.  Biochemical and Biophysical Research Communications (BBRC). 455(3-4): 205-211, 2014. doi: 10.1016/j.bbrc. 2014.10.148. Epub 2014 Nov 4. 

澤田典均.細胞間接着装置タイト結合と生体防御 -ヒト鼻粘膜上皮を中心に-.小児感染免疫,26(3): 395-401, 2014.

Kyuno D, Yamaguchi H, Ito T, Kono T, Kimura Y, Imamura M, Konno T, Hirata K, Sawada N, Kojima T. 

Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.  World Journal of Gastroenterology, 20(31): 10813-10824, 2014. doi: 10.3748/wjg.v20.i31.10813.

氷見徹夫,高野賢一,大國 毅,小笠原徳子,正木智之,小幡和史,堤 裕幸,小島 隆,澤田典均, 横田伸一.ウイルス性炎症における上気道粘膜の役割 -鼻粘膜上皮機能解析から炎症制御戦略を探る-.日本耳鼻咽喉科感染症・エアロゾル学会誌,2(1): 1-5, 2014.

Nomura K, Obata K, Keira T, Miyata R, Hirakawa S, Takano K, Kohno T, Sawada N, Himi T, Kojima T.  Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells. Respir Res, 15(1): 21, 2014.  doi: 10.1186/1465-9921-15-21, 2014.

 

 

2013年

Abiko Y, Kojima T, Murata M, Tsujiwaki M, Takeuchi M, Sawada N, Mori M.  Changes of tight junction protein claudins in small intestine and kidney tissues of mice fed a DDC diet.  J Toxicol Pathol, 26(4): 433-438, 2013.  doi:10.1293/tox.2013-0009, 2013.

Kojima T, Yamaguchi H, Ito T, Kyuno D, Kohno T, Sawada N.  Tight junctions in human pancreatic duct epithelial cells. Tissue Barriers, 1(4): e24894. Epub 2013 May 30. Review.

氷見徹夫,高野賢一,山下恵司,小笠原徳子,正木智之,小幡和史,堤裕幸,小島隆,一宮慎吾,澤田典均,横田伸一. 扁桃・アデノイドはなぜあるのか?鼻はなにをしているのか? - 小児の粘膜免疫・粘膜防御最前線 -. 小児耳鼻咽喉科,34(3): 239-244, 2013.

Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H. The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. PLoS One, 8(10):e75106, 2013. doi: 10.1371/jouranl pone.0075106, 2013.

Sugimoto K, Takasawa A, Ichimiya S, Murata M, Kimura H, Aoyama T, Gille JJ, Kuroda N, Shimizu H, Hasegawa T, Sawada N, Furuya M, Nagashima Y. Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with ‘capsulomas’ without FCLN gene abnormality. Pathol Int, 63(10): 510-515, 2013.  doi: 10.1111/pin. 12099, 2013.

氷見徹夫,高野賢一,大國 毅,小笠原徳子,正木智之,小幡和史,堤 裕幸,小島 隆,澤田典均.ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割.耳鼻咽喉科展望,56(4): 162-177, 2013.

Kojima T, Ninomiya T, Konno T, Kohno T, Taniguchi M, Sawada N. Expression of tricellulin in epithelial cells and non-epithelial cells. Histol Histopathol, 28(11): 1383-1392, 2013. Epub 2013 Jun 13.

Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R , Ogasawara N, Masaki T, Fuchimoto , Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T, Sawada N. Regulation of tight junctions in upper airway epithelium. Biomed Res Int, 2013; 2013 947072. doi: 10.1155/2013/947072. Epub 2012 Dec 29. Review.

Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N. Regulation of tight junction by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano. Cell Tissue Res, 354(2): 481-494, 2013. doi: 10.1007/s00441-013-1676-9. Epub 2013 Jul 3. 

Hirakawa S, Kojima T, Obata K, Okabayashi T, Yokota SI, Nomura K, Obonai T, Fuchimoto J, Himi T, Tsutsumi H, Sawada N. Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells. J Med Virol, 85(12): 2141-2150, 2013. doi: 10.1002/jmv.23718. Epub 2013 Sep 5.

Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N. Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One, 8(9): e70225, 2013. doi: 10.1371/journal.pone.0070225. eCollection 2013.

Eto K, Kawakami H, Kuwatani M, Kudo T, Abe Y, Kawahata S, Takasawa A, Fukuoka M, Matsuno Y,

Asaka M, Sakamoto N. Human equilibrative nucleoside transporter 1 and Notch 3 can predict gemcitabine effects in partients with unresectable pancreatic cancer. British Journal of Cancer, 108,1488-1494, 2013. doi: 10.1038/bjc.2013.108.

Kojima Y, Takasawa A, Murata M, Akagashi K, Inoue T, Hara M, Tokunaga Y, Minase T, Hasegawa T, Sawada N. A case of urothelial carcinoma, lipid cell variant. Pathol Int, 63(3):183-187, 2013.

Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N. Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. Carcinogenesis, 34(6): 1232-1243, 2013.  doi: 10.1093/carcin/bgt.057. Epub 2013 Feb 6.

Fuchimoto J, Kojima T, Okabayashi T, Masaki T, Ogasawara N, Obata K, Nomura K, Hirakawa S, Kobayashi N, Shigyo T, Yokota SI, Fujii N, Tsutsumi H, Himi T, Sawada N. Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells. Med Mol Morphol, 46(4): 203-209, 2013.  doi: 10.1007/s00795-013-0024-1.  Epub 2013 Feb 5. 

Sawada N. Tight junction-related human diseases. Pathol Int, 63(1): 1-12, 2013.

                                                                                               

Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Cell Tissue Res, 351(1): 73-84, 2013.  doi: 10.1007/s00441-012-1512-7. Epub 2012 Oct 17.

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